• Conde-Agudelo A, Romero R, Rehal A, Brizot ML, Serra V, Da Fonseca E, Cetingoz E, Syngelaki A, Perales A, Hassan SS,Nicolaides KH.
  • Am J Obstet Gynecol 2023:S0002-9378(23)00317-4.

This systematic review evaluated the efficacy of vaginal progesterone in randomized controlled trials for the prevention of preterm birth <34 weeks’ gestation and adverse perinatal outcomes in twin gestations. It concluded that vaginal progesterone does not prevent preterm birth, nor does it improve perinatal outcomes in unselected twin gestations, but it appears to reduce the risk of preterm birth occurring at early gestational ages and of neonatal morbidity and mortality in twin gestations with a sonographic short cervix. However, more evidence is needed before recommending this intervention to this subset of patients.